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  • Clinton Pinto posted an article
    More than 1,000 accredited investors attended the 2nd annual virtual Investor Capital Expo see more

    $20 million in expected funding for participating companies. Sparrow, Orion Biotechnology Win Most Valued Company awards as voted on by investor attendees

    SEATTLE, WA—More than 1,000 accredited investors attended the 2nd annual virtual Investor Capital Expo hosted by Keiretsu Forum. The Expo, which showcased 21 premier growth-stage companies and a robust lineup of keynote presenters at its East Coast and West Coast sessions, also had more than 50 angel groups, investors from 100+ Family Offices, corporate partners, and other investment professionals attending the event. Underscoring the industry shift from in-person, geographically-focused investing, coupled with the power of large angel networks like Keiretsu Forum, a total raise of $20 million is projected for Expo participating companies. 

    “The shift of Angel investing to a mainly virtual model has been a boon for accredited investors looking to diversify or catch that next unicorn no matter the geographic location of the investor or the company. It has also opened the floodgates for investors keen to help companies that are impactful, sustainable, and more diverse,” said Randy Williams, Keiretsu Forum chairman and founder.

    Sparrow, developing AI-powered personalized feedback solutions that improve individual athletic performance, won the coveted “Most Valued Company” at the West Coast session. Orion Biotechnology, developing next-generation G Protein-Coupled Receptor (GPCR)-targeted therapeutics for the treatment of cancer and other serious diseases, was named “Most Valued Company” at the East Coast session. Both companies were hand-picked by attending angel investors as a stand-out innovator amongst a group of highly touted, entrepreneurial companies from the U.S. and Canada.

    About Keiretsu Forum
    Keiretsu Forum is a global investment community of accredited private equity angel investors, venture capitalists, and corporate/institutional investors. Keiretsu Forum was founded in 2000 by Randy Williams. Keiretsu Forum today is a worldwide network of capital, resources and deal flow with over 50 chapters on three continents. Keiretsu Forum members invest in high-quality, diverse investment opportunities. To date, it has invested over $900 million in 2000+ companies.

  • Clinton Pinto posted an article
    LumiThera Inc., announced the final topline data from the ELECTROLIGHT pilot study. see more

    SEATTLE, July 21, 2021 /PRNewswire/ -- LumiThera Inc., a commercial stage medical device company offering a photobiomodulation (PBM) treatment for ocular damage and disease, today announced the final topline data from the ELECTROLIGHT pilot study in intermediate dry AMD patients. 

    A total of 23 eyes from 15 subjects with Dry AMD were enrolled into the prospective clinical study and treated with PBM using the Valeda® Light Delivery System (3 times per week for 3 weeks). Eight Caucasian males and seven females were enrolled with a mean age of 75.1 years (65-93 years). The mean time since AMD diagnosis was 5.0 years (0-14 years). Subjects were tested for safety and functional vision improvements using the Diopsys electroretinogram (ERG) device. ERG is a diagnostic test that measures the electrical activity of the retina of the eye in response to a light stimulus. All subjects were tested at weekly intervals for ERG function prior to the start of the next week of PBM treatments. The study followed the patients out to 6 months. The study was conducted by Dan Montzka, M.D. and Larry Perich, D.O. at the Perich Eye Center (New Port Richey, Florida).

    Multi-luminance Electroretinogram (ERG) Magnitude AUC improved by 14.4% from baseline after completion of the Month 1 treatment and showed a 9% improvement at 6 months in the ITT population. A positive correlation between multi-luminance ERG and best corrected visual acuity (BCVA) was seen (p < 0.05) following initial PBM treatment. Positive correlations between multi-luminance ERG and fixed luminance (R = 0.870) and chromatic ERG outcomes (R = 0.676) were also reported in the Month 1 interim analysis.

    Subjects showed approximately 12.8 ± 0.98 letter improvement in BCVA at Month 6 compared to BL scores. Mars Contrast Sensitivity (CS) also showed improvement from BL to Month 6 at 40 cm (0.202 log + 0.02), 80 cm (0.197 log + 0.02) and 120 cm (0.28 log + 0.03).

    "Valeda provided statistically significant and sustained improvements in BCVA, CS and multi-luminance ERG function from baseline out to Month 6 time point following 9 PBM treatments," stated Dan Montzka, M.D. "Diopsys multi-luminance ERG is an early, sensitive and quantitative measure of visual dysfunction in dry AMD patients."

    "The study further confirms previous LIGHTSITE I and II studies that the Valeda Light Delivery System improves visual function," stated Larry Perich, D.O. "The subjects were very pleased with the results of their treatments and no safety issues were seen."

    Diopsys ERG testing is a powerful and quantitative diagnostic that can be coupled with LumiThera's PBM treatments to characterize early patient benefits on visual function," indicated Joe Fontanetta, CEO, Diopsys. "These results of this work will allow physicians to diagnose, treat and monitor patients and provides physicians a solution for a disease with limited treatment options."

    "We are strong supporters of treating degenerative disease early to slow the progression of vision-threatening disease." stated Clark E. Tedford, Ph.D., President and CEO, LumiThera, Inc. "The key in chronic ocular disease is early diagnosis, treatment and monitoring and we hope studies such as this pilot pave the way to a more preventative approach. The patients in the ELECTROLIGHT study are similar in demographics as the LIGHTSITE III US study in terms of time from dry AMD diagnosis, AREDs use and age. Previously, we reported the US LIGHTSITE III dry AMD trial fully enrolled 100 subjects in 1Q of 2021 and is continuing to move forward with the 13-month efficacy timepoint for all patients in 1Q of 2022."

    About AMD

    AMD is a leading cause of vision loss for people age 65 and older.  Losing central vision can make it harder to see faces, drive, or do close-up work like cooking or fixing things around the house.  The overall prevalence of AMD is estimated to increase 7-fold with age, from 4.2% in those aged 45–49 years, to 27.2% in those aged 80–85 years. Globally, the prevalence is estimated to increase by 20% between 2020 (195.6 million) and 2030 (243.3 million).

    About Diopsys

    Diopsys, Inc. is a leader in modern visual electrophysiology medical devices that help eye care professionals analyze the entire visual pathway for visual and neuro-visual disorders. The company provides both Visual Evoked Potential (VEP) and Electroretinography (ERG) vision testing technology. It is this technology that powers Diopsys, Inc.'s medical devices – the Diopsys® NOVA, Diopsys® ARGOS, and Diopsys® RETINA PLUS ERG and VEP Vision Testing System product series and the Enfant® Pediatric VEP Vision Testing System.

    About LumiThera Inc.

    LumiThera is a commercial-stage medical device company focused on treating people affected by ocular damage and disease including dry age-related macular degeneration, a leading cause of blindness in adults over 65. The company is a leader in the use of PBM for treatment of visual disorders. The company is commercializing the office based Valeda Light Delivery System to be used by eye care specialists as medical treatments.

    The Valeda Light Delivery System has been granted authorization to use the CE Mark by an EU Notified Body as required for commercial use in the European Union only. Valeda is not approved for use by the Food & Drug Administration (FDA) in the USA.

     

    Credit: 

  • Clinton Pinto posted an article
    Also ranked on the Global Stage as the ‘2nd Most Active early and late-stage investors' see more

    Also ranked on the Global Stage as the ‘2nd Most Active early and late stage investors’

     

    SAN FRANCISCO, CA—April 13, 2021, Setting a standard for most active investors three years running, Keiretsu Forum, the world’s largest angel investor network, today announced Pitchbook has released its 2020 Annual Global League Tables highlighting Keiretsu Forum as the U.S. Region’s #1 and # 2 Most Active Late and Early Stage investors.

     

    Impressively on the Global Stage, Keiretsu Forum was ranked the # 2 Most Active, Early, and Late Stage investors. Keiretsu Capital, the exclusive worldwide fund partner of Keiretsu Forum, continues to be a top-tier funder of late-stage investment deals in the network.

     

    Keiretsu Forum is known by investors and entrepreneurs alike for its proven approach for originating quality deal flow and success syndicating early and late-stage investment opportunities around the world.

     

    2020 was a banner year for Keiretsu Forum, with the organization achieving a record 314 fundings (including follow-on fundings) into seed, early-stage and late-stage companies in 2020. Deal activity increased approximately 16% compared to 2019, with Life Science, Medical Devices, Environmentally and Sensitive/Aware, and solution-driven Technologies attracting the most capital.

     

    In 2020 Keiretsu also expanded its international footprint, now with 50+ chapters on four continents.

     

    About Keiretsu Forum

    Keiretsu Forum is a global investment community of accredited private equity angel investors, venture capitalists and corporate/institutional investors. Keiretsu Forum was founded in 2000 by Randy Williams. Keiretsu Forum today is a worldwide network of capital, resources and deal flow with 50+ chapters on four continents. Keiretsu Forum members invest in high-quality, diverse investment opportunities. To date it has invested over $900 million in 2000+ companies. The community is strengthened through its involvement in social and charitable activities.###